Coinbase identifies five key blockchain areas to watch in 2025: pro-crypto regulations, rapid growth in crypto ETFs, global adoption of stablecoins, tokenization of real-world assets, and advancements in DeFi. The U.S. is expected to establish a comprehensive regulatory framework, while stablecoins could significantly increase their share of the money supply. Additionally, the tokenization market is projected to reach at least $2 trillion, and DeFi continues to evolve with a total value locked of $120 billion.